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[11-30] 學術报告:殺菌劑環吡酮胺用作新型抗癌劑的研究
文章来源:农业虫害鼠害綜合治理研究国...     发布時間:2017-11-29

  題目:殺菌劑環吡酮胺用作新型抗癌劑的研究 

  The fungicide ciclopirox as a novel anticancer agent  

  報告人黃世樂 博士 

  美國路易斯安那州立大學醫學院生化與分子生物學系教授 

  Dr. Shile Huang, Associate Professor, Department of Biochemistry & Molecular Biology, School of Medicine, Louisiana State University, Shreveport, LA, USA 

  時間20171130(星期四)上午0945 

  地點:中科院動物研究所C101會議室 

  報告人研究工作简介 

  黃博士主要從事信號轉導和腫瘤發生的研究,主要研究方向爲mTOR信號在腫瘤發生和腫瘤細胞轉移過程中的作用。近年來,其實驗室發現mTOR信號除調節細胞生長、增殖和分化外,還可以調節細胞運動。此外,該實驗室還研究從天然植物中分離出來的物質(如:姜黃素、青蒿素等)的抗癌活性並探究其作用機理。 

  Dr. Huang's major research interests include mTOR signaling pathway and tumorigenesis. Recently, his laboratory has demonstrated that disruption of mTOR complexes by silencing the expression of RAPTOR or RICTOR down-regulates cell motility, implicating critical roles of mTOR in cell motility. In addition, the laboratory is investigating anticancer mechanisms of small molecules such as natural products including curcumin, cryptotanshinone, artemisinin, and an off-patent synthetic fungicide ciclopirox olamine. Notably, curcumin, artesunate (a water-soluble artemisinin derivative), and ciclopirox olamine are undergoing initial clinical trials as novel anticancer agents. Huang’s lab recent studies indicate that these compounds may execute their anticancer activities by inhibiting cell proliferation, inducing cell death, suppressing cell motility, or inhibiting angiogenesis/lymphangiogenesis. 

  邀請人:伍一軍(010-64807251;wuyj@ioz.ac.cn 

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